Paperguide launches AI systematic review software with dual review

Paperguide launched a new systematic review platform for corporate evidence teams that combines AI-assisted screening with independent dual review, PRISMA reporting and a full audit trail. The product is aimed at HEOR, pharma and medical device teams that need faster, reproducible reviews for clients and regulators.

Why it matters: - Systematic reviews are central to health economics and outcomes research, clinical evaluation reports and post-market surveillance. - The new workflow is designed to reduce missed studies, shorten screening timelines and preserve an auditable record for clients and regulators. - Paperguide says teams using the system have cut screening from about four weeks to one.

What happened: - Paperguide launched Paperguide Systematic Review, an AI-assisted software product for corporate teams that run literature reviews and evidence synthesis. - The platform centers on Dual Review, where two reviewers screen each study independently and a designated resolver makes the final call on disagreements. - The product is available now to Paperguide Evidence and Enterprise plan customers. - A product page is available here: More information

The details: - Dual Review keeps each reviewer blind to the other reviewer’s include and exclude choices during screening. - Every disagreement is flagged automatically. - Each final conflict decision is recorded with a rationale for audit purposes. - Teams can also use an AI-led mode where Paperguide’s AI screens first and reviewers keep final authority. - The platform generates PRISMA flow reporting directly from underlying screening decisions. - The system keeps a full audit trail showing who decided what and when. - Screening decisions connect to structured data extraction and citation-grounded drafting. - Shared projects and workspaces support concurrent review work across a team. - Saved searches can be re-run for surveillance updates without rebuilding the search strategy. - The platform keeps the search strategy, screening decisions, conflict resolutions and PRISMA counts together in one project. - Enterprise features include single sign-on, role-based access control and organization-wide administration. - Paperguide says SOC 2, ISO 27001 and GDPR compliance work is underway. - Existing libraries can be imported from Zotero, Mendeley, RIS and BibTeX files.

Between the lines: - The launch targets a persistent workflow problem in evidence synthesis: teams often split second-review duties across spreadsheets, email and separate tools. - Paperguide is positioning the product as a way to keep dual review and documentation rigor without adding weeks to the timeline. - The pitch is especially relevant for regulated work, where reproducibility and traceability matter as much as speed. - Paperguide cites outside research showing that single-reviewer abstract screening missed 13% of relevant studies in a 2020 randomized trial, compared with 3% for dual screening. - Paperguide also cites an analysis in BMJ Open that found a mean of 67.3 weeks from registration to publication for systematic reviews.

What's next: - Paperguide will likely use the launch to expand adoption among HEOR, pharma and medical device teams that need audit-ready review workflows. - The company is also continuing compliance work tied to SOC 2, ISO 27001 and GDPR. - Broader use could follow from imports from common reference managers and file formats, which lower the barrier for existing teams.

The bottom line: - Paperguide is trying to make systematic reviews faster without weakening the documentation and dual-review controls that regulated evidence teams need.